In tonight's episode, episode 6, Leo is presented with Ayahuasca after being bitten by a poisonous snake. Following consumption, a sex ritual takes place between him and this hot native Incan chick. Then it appears he's in the spirit realm where souls are walking by. And then he sees Giuliano Medici's spirit and they talk... And then he walks down an empty hallway to where he finds a guy in front of the Mona Lisa painting and they talk for a bit, and then he moves on and sees his older senior self.
After talking with his older self, he then is called to come back to the land of the living, and he sees Giuliano's spirit again and he starts running down the hallway passing all these spirits, which at one point some tried grabbing him trying to hold him back it seemed but then this one woman's spirit came up (who was just sacrificed by Riario because he was forced to do so) and helped him get loose and said for Leo to tell Riario that she forgives him. Leo then returns to the land of the living and receives the antidote to the snake poison.
They could've really amped that Ayahuasca sequence up i think, and made it more awesome, but atleast they mentioned it, that's enough for me lol. The scene starts at 16 minutes and 30 seconds in and the rest is in sequence form through the episode. It's awesome how Ayahuasca is getting to become more known about.
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Quick sneak peak -
https://www.youtube.com/watch?v=7RwaL2oUIlU