I figured this might be the forum to ask!

Does anyone have information on inhibiting the metabolites that breakdown cocaine? (for the goal of coca leaf potentiation & duration) Maybe Peruvian secrets to getting the most out of your leaf? I've heard they hold 3 leaves together and blow on them before quidding as a thank you to the earth and it's spirits, but that's more metaphysical potentiation eh?

I belief that both harmala's as hypericine from saint john'sworth inhibit the breakdown of dopamine. Cocaine's effects are based on elevated dopamine and noradrenaline, so potentially those MAOI's could significantly boost the effects of coca leaves.

I wouldn't combine the two (harmala's and hypericine) and be moderate on saint john's worth.

Tyrosine metabolises into dopamine. Taking a tyrosine suplement may have very mildly potentiating effects as well.

Have you tried using lime or another base? This helps the alkaloids (of which cocaine is only one - the coca leaf has a number of alkaloids that synergetically contribute to the effects) absorb into the bloodstream. Take a small amount of coca leafs, chew them with a smaller amount of lime - I judge this by taste - then tuck the resulting quid into the cheek. This technically isn't potentiation but the extra absorption magnifies the effects, fantastic.

Heres a pretty good rundown on cocaine and its interactions, including potentiation/inhibition, with other medications.I think there are significant cardiac hazards if you get it wrong and over-do the potentiation.

http://rx-s.net/weblog/more/cocaine_interactions/

ok coca leaves are in the border of entheogens anyway i think you mustn't combine them with maoi like harmala couse MAOi with stimulants are bad afaik..

Agreed - it's only one case but I tried to take a quid of coca leaf to help with the stomachache after drinking ayahuasca, and the aya potentiated the coca leaf to the point that it was quite unpleasant - just like taking an overdose of caffeine or coca leaf, but the amount of leaf I took was very small (I was aware of the potentiation so took very little, but even that small amount was magnified many-fold). What about the lime?

Tobacco

thank you very much for the info, what about an mao b inhibitor like selegeline or various herbs (like yohimbe/ fo-ti / cat's claw?)...? maob is specific for phenethylamine and dopamine and adrenaline if i recall correctly, would taking this inhibit the breakdown of the dopamine or the cocaine? I want to boost the coca moreso than just a specific site. I've also heard that coca has serotonin reuptake inhibiting properties as well, not just adrenaline and dopamine, i wonder what caapi would be like mixed...

Also I imagine L-Dopa or mucuna pruriens would be a good combination? Mucuna contains beta-carbolines as well as L-Dopa, serotonin, bufo, dmt, 5-meo, imagine a dual serotonin dopamine organic psychedelic expansion overload with caapi, coca & pruriens tea!