Hello,
Disclaimer : I am not a medical professional and nothing here can be taken as medical advice. Please check with your physician.
Perhaps the following can help you:
Concerning MAOIs: This source seems to indicate that it 'may' be OK but does not refer to any scientific research:
Quote:"Purely opiate-acting analgesics, such as morphine and buprenorphine
may be used safely with MAOIs, but
may require a dosage adjustment."
source The following source does refer to research but is very old, concerns rabbits and is performed with a specific MAOI: Phenelzine (non-selective and irreversible MAOI). (PDF available)
Quote:"In the model used buprenorphine, in contrast to pethidine, showed
no interaction with the MAO inhibitor phenelzine."
source This research here below is more recent and seems more relevant (PDF available):
Quote:"Morphine, codeine, oxycodone and buprenorphine are known not to be SRIs, and
do not precipitate serotonin toxicity with MAOIs."
source The following explains it nicely:
Quote: There are two types of dangerous reactions that can occur with an MAOI and certain other drugs. The first is Serotonin Toxicity or Syndrome (ST or SS). This is the result of using a serotonin reuptake inhibitor (SRI) and an MAOI concurrently. [...] The second dangerous reaction is a sudden rise of blood pressure, [...]
Analgesics such as aspirin, tylenol, NSAIDS and the COX2 drugs are
safe as are codeine, oxycodone,
buprenorphine and morphine. [...]
Again,
analgesics that lack serotonin reuptake properties are thus safe and include aspirin, acetaminophen, nonsteroidal anti-imflammatory drugs, codeine, oxycodone
buprenorphine, morphine, and the aforementioned fentanyl.
source Concerning DMTQuote: "I have been taking 8mg suboxone (buprenorphine) for 1 year. Through-out this year I have also done DMT on many occasions both at the very beginning of my suboxone taking period as well as recently. I have also taken DMT on many occasions without the use of any opiates. I have noticed no alterations in the subjective effects of DMT when an opiate is ingested. Nothing is potentiated nor is anything attenuated."
source Concerning brewing with A. Acuminata and P. HarmalaThis can help:
https://www.dmt-nexus.me...aspx?g=posts&t=78449
Considering a slow start with ONLY Peganum harmala (or maybe Banisteriopsis caapi) Since I see no problems with DMT itself, only possibly with MAOIs concerning buprenorphine, it might be interesting to consider to start the work with Syrian rue (P. harmala) by itself before you dive in with a full ayahuasca brew. This might seem weird but :
Quote:...even if i really love dmt, i feel that the neo-shamanic practice in the west sometime exaggerate its [DMT] importance in relation with the β-Carboline alkaloids, that are often thought about just as a way to metabolize the dmt, when for me they are a very important part, a crucial part of the magic of ayahuasca.
source You probably know what beta-carboline alkaloids are, but to be sure :
Quote:Harmaline, harmine, harmalol, harmol and tetrahydroharmine were identified and quantified as the main beta-carboline alkaloids in P. harmala extracts.
source And here is an indication that Harmaline itself already could help you:
Quote:Peganum harmala is characterized as one of the monoamine oxidase and serotonin inhibitors. The
alkaloid harmaline plays an important role in eliminating some of the withdrawal symptoms by influencing the opioid circuits, receptors, limbic system and autonomic nervous system in the brain.
Studies have found that oral administration of Peganum harmala powder can reduce the incidence of withdrawal symptom 30.source More generally, the following links ayahuasca with buprenorphine.
Quote:Buprenorphine, ketamine, or ayahuasca can reduce the level of depression or anxiety.
An Amazonian botanical hallucinogenic substance - Ayahuasca - includes dimethyltryptamine, which is an agonist of 5-HT2A receptor, and also harmine, which is a monoamine-oxidase A inhibitor. Ayahuasca lower the severity of depression and anxiety. A single dose of ayahuasca lessens the level of depression and anxiety very promptly.[11,12]
Likewise, buprenorphine medication can reduce the level of anxiety and depression straightaway.[13,14]
source
Personal noteIt seems ayahuasca might be of specific interest for you to pursue. It might be able to help you with your 'opiate problem', wean you off of buprenorhpine and simultaneously take you to 'move to the next step'.
This being said, again, I am not a medical professional! The above is not exhaustive and I might have overlooked some important variable(s). Perhaps you can print this material, go to your doctor and let him/her give you some advice.
In any case, if you go through with it, be careful and go slow! From your post, I derive that you would be travelling without 'supervision'. Not merely buprenorphine itself but also thoughts and feelings of insecurity or fears concerning buprenorphine might be a bit of an obstacle here despite your long experience with entheobotanicals. Working with P. harmala or B. caapi beforehand by gradually increasing dosage might help dissolve some of those issues and give you the confidence to allow ayahuasca to guide you fully.
If you are able to, I recommend you search for someone with experience to guide you optimally, but speaking from personal experience, this might not be 'absolutely' necessary. It depends in part on who you are, the problems you are dealing with and how you approach it. Follow your gut with care.
However, at the very least, take all necessary precautions described
HERE, and make sure someone is around that is sober, makes you feel safe and can help you if any problems arise. If you live remotely (I suspect you live in Australia), I advise you to ensure you have access to medical facilities in case something goes sideways.
I wish you all the best in your journey.
May the Verse be with you...