Simultaneous Production of Psilocybin and a Cocktail of β‐Carboline Monoamine Oxidase Inhibitors in - Science

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Simultaneous Production of Psilocybin and a Cocktail of β‐Carboline Monoamine Oxidase Inhibitors in

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benzyme

#1
Posted : 12/29/2021 3:05:43 PM

Simultaneous Production of Psilocybin and a Cocktail of β‐Carboline Monoamine Oxidase Inhibitors in 'Magic' Mushrooms

"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck

benzyme

#2
Posted : 1/1/2022 8:18:48 PM

This is an excitation scan, from 208 nm to 360 nm, Em 440 nm.

Different mobile phase (50 mM Amm. Acetate, ACN). It coincides with the results reported in this paper.

benzyme attached the following image(s):

psilo extract in ACN.jpg (254kb) downloaded 84 time(s).

"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck

highlightprotein

#3
Posted : 1/1/2022 11:12:42 PM

Do I understand correctly that they are saying mushrooms contain MAOIs that potentiate psilocybin?

My understanding was that mushrooms contain no MAOIs. Is this a new discovery or is this old news?

benzyme

#4
Posted : 1/1/2022 11:43:21 PM

It is a recent (2020) discovery. Beta-carbolines are a latter by-product of tryptophan metabolism, via Pictet-Spengler cyclization. This may either be achieved enzymatically, or thermodynamically with H+ and a methylating reagent.

"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck

Quetzal7

#5
Posted : 1/3/2022 8:33:47 AM

I couldn't see any clear quantitative data ; we speaking about how much IMAO here ?
Any practical interpretation would be welcome =)

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