downwardsfromzero wrote:They're called dissociative drugs because they block the transfer of sensory information into the brain. The hallucinogenic effects occur partly because the brain starts making stuff up to compensate for the lack of input. That's a gross over-simplification, of course.
Part of the antidepressant effect from dissociatives occurs through the stimulation of axonal dendrite growth - the brain grows new connections. One way of seeing this might be that it makes new possibilities apparent, thereby offering a route around the entrenched patterns of thought and behaviour that can make depressive states so intractable.
I'll admit here, I'd need to go over the literate again before being able to go into more depth on this one. There are pointers toward this type of information on the forum if you search for them. It can be pretty tricky working out what terms to use in order to optimise that search, especially if English isn't your first language. The technical nature of the matter compounds the challenge. Thanks a lot for this detailed information, explains so much, this is exacly what was looking for. dragonrider wrote:I find it a pretty boring substance anyway. It does have a very distinctly psychedelic edge to it, at larger doses. I even get quite powerfull LSD-like visuals from it. But it remains a very shallow drug for me. From a recreational point of view, wich is the main reason for most people taking it, i even find it pretty inferior to cannabis, wich is a thousand times safer. Even though it can be much more powerfull. And it is unbelievable how it dumbs you down. I can not form a single coherent thought when i'm on it. I once tried to open a carton of orange juice when i had taken it. And for some reason it had one of those child-safe screwcaps on it. You know, one of those screwcaps that you have to push down and screw at the same time. I don't know why the hell this would be needed for cartons of orange juice, maybe the manufacturer thought it would be an extra selling point or something. But i just couldn't open it  That's how stupid you become on this substance. I also don't like the taste and smell of it. If you snort it, it realy leaves a toxic smell and taste, i find. No, from a psychedelic point of view this is not a gem in my opinion. Yes i don't get it how this psychedelic mindframe works on the user. I don't think i would try it, is not easily available where i live, and i don't have any interest, people say that you feel like talking more about mysterious things and feels like you're on the brink to discover something new, like everything makes sense and fits perfecly, seems it makes you connect weird dots on your head, and make connections with things that are not correlated whatsoever.
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I've heard similar reports. The feeling of being on the brink of understanding things of great importance, but in the end it turns out to be an empty illusion and no knowledge is gained. Very different from psychedelics, which do offer clear and direct answers and provides insight into the true nature of things. I feel it's a fool's errand to hope to gain anything lasting from ketamine; it seems to be a false messenger. But your mileage may vary of course.
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