Interestingly, extra-oral bitter receptors are populated throughout mammalian organ systems. Growing evidence reveals that they participate in health maintenance broadly...cardiopulmonary, gastrointestinal, nervous system, hepatic, renal and immune functions against pathogens and malignancy.
Many phyto-nutrients, including alkaloids, are bitter substances. It seems that the, "poison is in the dose", applies bigly re bitters in the diet. Really cool topic, please explore!
https://www.urbanmoonshi...health-emerging-research