I'm not an opiate user (I'd much rather go sideways than up or down) but a few summers back I decided to grow some poppies and slice the pods just to see what was involved in the process and to experience the taste and smell of opium.
Then I had the (as it turned out, not so bright) idea of seeing what happened if I hit all three of the major/"classical" opioid receptors at the same time. The morphine in opium has affinity for both the mu and delta receptors, salvinorin-A binds to the kappa receptor.
I placed a small amount of raw opium (just enough to elicit a noticeable response) and a small to moderate amount of a 40x Salvia extract (just enough to get some visuals) in a pipe then hit it with a torch lighter... the result was unlike either of the two drugs taken alone. I expected/hoped-for a mild Salvia experience without or with less dysphoria, perhaps even with some euphoria, instead I got profuse sweating (much more than Salvia alone) and what must have been a strong spike in body temperature because my glasses completely fogged up (again, much more than Salvia alone). There were no visuals (just blackness for about a minute) and none of the "twisting" feeling I consistently get from Salvia. While the experience wasn't dysphoric it certainly wasn't euphoric. It was a very unnerving experience and I was glad I hadn't used more of either drug in the mix.
Take care with your experiments,
- Tse
Two things to keep in mind:
1) It is all lies.
2) There is no privacy on the Internet.