I always found it interesting that betacarbolines also show up in the Tiliaceae. Do you have access to this plant? Just how widespread is 'widespread'? IIRC, Shulgin and/or Ott listed
Grewia villosa as containing 6-MeO-harman derivatives as well, although it would be wise to check for conspecificities and synonyms with all this stuff. And, incidentally, cowitch,
Mucuna pruriens has 6-MeO-something listed among its constituents as well.
Furthermore, it seems we don't really know anything about the pharmacology of these 6-MeO compounds. In that respect, the guinea pig uterus contraction result might be seen by some as a promising indication of interesting central activity.
Quote:7-Substituted analogues of harman are well known and widely distributed alkaloids; the 6-substituted compounds which were found in this investigation are rare and only found in some Virola species (Allan and Holmstedt, 1980) and in Grewia mollis (Rosler et al., 1978; Allan and Holmstedt, 1980). Because no compounds were isolated from the roots which could be responsible for their use in delayed afterbirth, ethanolic extracts were tested on the guinea pig uterus, showing strong contractions which were not blocked by atropine. Contractions caused by the extract and 5-HT (serotonin) were both blocked with the semisynthetic ergot alkaloid methysergide. On the contracting uterus methanol extracts of the roots gave an increase of the frequency and force of the contractions.
Paris (1956) and Paris and Theallet (1961) reported that extracts from the bark of different Grewia species, amongst them Grewia bicolor hss. showed an oxytocic activity. Although they isolated an active constituent these authors could not establish its structure. Research is now being carried out to isolate and identify the oxytocic principle of Grewia roots.
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