WITH MESCALINE

(with 100 mg harmaline, 60 mg mescaline (3,4,5-trimethoxyphenethylamine) [20 min]) “At two hours I was in a pleasant state of physical relaxation, a fine sense of well being, and I found music most enjoyable. From then to the fourth hour, thoughts flowed freely, and it became obvious that insight was a major part of this experience. Normally unconscious thoughts were easily available. It was as if I could observe my mind in operation, as facts were weighed to form conclusions. By the sixth hour music was a thing of beauty, with the higher notes crisp and clear. The harmaline has probably worn off. Sleep at eight hours, and the next day was without any adverse effects. This was a remarkable experience, the insight of TMA, and the relaxation of MDMA.”

(with 150 mg harmaline, 100 mg mescaline [15 min]) “A stomach ache developed at about 45 minutes, followed by a mild nausea which occurred intermittently throughout the next six hours. I felt comfortable, although there was a slight discoordination at about two hours. Walking was never a problem but did require more concentration than normal. Colors on the television were obviously more intense, and highly saturated at this point and moderate photophobia developed. Even a fire in the fireplace was distracting, and stereo was best enjoyed in the dark. Attempts at sleep did not work until the ninth hour. Upon awakening there was a feeling of dehydration but otherwise no ill effects. Mild looseness of stools was present later that morning. Since experiments using only mescaline at doses between 80 and 120 mg resulted in no CNS effects at all, it seems clear that the MAO blocking effects of the harmaline were crucial to this experience.”

Mild looseness of stools was present

Quoted from Shulgin's TiHKAL:


This is a bit different from your trip report because rue harmalas are a mix of harmala and harmaline. It takes about 200-220mgs of rue alks (from manske) to get me fully inhibited. I've got to try this because it would be a great way to conserve precious mescaline. It seems like the lower dose was more enjoyable. I wonder if 300mgs mescaline and 150mgs harmalas might be a bit much. Looking forward to trying this myself. Just be carefull mixing phens and maoi's....we all know the dangers.

Joe ----

I offer my humble advice that you should include Caapi in the mix....I have seen observed that caapi and mescaline are a PERFECT synergy of two legendary plant teachers working in harmonious concert... Rue is effective but a rough ride if you take 2 much.... I would recommend combining mostly rue, lots of caapi and then ...your mescaline....YUM!

Don't be scared to add LSD to the mix ....BANG! POW! ZAP! Oh yes and be sure to smoke your DMT sir....ZOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM to the mooon.

I took 250mgs today with 40mgs dmt and had a HORRIBLE experience...though yes still very healing in the long run..but I had full on body twitches and shakes for a good two hours. I think I just overdid the rue.

That sucks to hear. I've dosed 220-250mgs of rue alks and never had those symptoms. Usually just causes a rearend purge thats over by the first hour. Lots of variables here like body weight and purity of your rue alks.

Check out my TR in the pharma section. 230mgs rue alks and 120mgs DMT. Not fun...too much DMT.

Next trip I'll try 220mgs rue alks and 125mgs mescaline HCL. Harmalas first and mescaline 30 mins later.

I'll report back.

why not rue during the mesc peak at 3 or so hours after dosing mesc? wouldnt synergistic climax be the objective?

Ive wanted to try dmt on cacti for awhile but im afraid it would blow me too far away

Something to keep in mind with cactus + harmala (rue or caapi) combinations, you will get a synergy between the two substances but not much of a direct potentiation.

Why? Harmala alkaloids are MAO-A inhibitors, the MAO-A system preferentially breaks down indoles whereas the MAO-B system preferentially breaks down phenethylamines. Also, although some mescaline may be metabolized by MAO-B, most of it is broken down by another enzyme system, catechol-O-methyltransferase I believe.

􀀁-Carboline Alkaloids: Biochemical and Pharmacological Functions
Rihui Cao1, Wenlie Peng1, Zihou Wang2 and Anlong Xu*,1

1Guangdong Key Laboratory for Pharmaceutical Functional Genes and Center for Biopharmaceutical Research, School of Life Sciences, Sun Yat-sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P.R. China

2Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xian Nong TanStreet, Beijing, 100050, P.R. China


Abstract: 􀀂-Carboline alkaloids are a large group of natural and synthetic indole alkaloids with different degrees of aromaticity, some of which are widely distributed in nature, including various plants, foodstuffs, marine creatures, insects, mammalians as well as human tissues and body fluids. These compounds are of great interest due to their diverse biological activities. Particularly, these compounds have been shown to intercalate into DNA, to inhibit CDK, Topisomerase, and monoamine oxidase, and to interact with benzodiazepine receptors and 5-hydroxy serotonin receptors. Furthermore, these chemicals also demonstrated a broad spectrum of pharmacological properties including sedative, anxiolytic, hypnotic, anticonvulsant, antitumor, antiviral, antiparasitic as well as antimicrobial activities. In this review, we summerized the biochemical and pharmacological functions of 􀀂-carboline alkaloids.

europharmacology. 2011 Jun;60(7-:1168-75. doi: 10.1016/j.neuropharm.2010.10.016. Epub 2010 Oct 27.

Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression.
Li Y, Sattler R, Yang EJ, Nunes A, Ayukawa Y, Akhtar S, Ji G, Zhang PW, Rothstein JD.
Source

Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.